Recent advancement in treatment of head and neck cancer has greatly improved the survival rates. However, radiation therapy and chemotherapy often come with significant toxicities and long-term complications. Acupuncture as a novel therapy has been used in the management of symptoms associated with head and neck cancer treatment. These symptoms include pain, fatigue, dry mouth, dysphagia and neuropathy. A case with a long-term use of acupuncture during and post radiation therapy was presented, with discussions of evidence from clinical trials.