Representative Publications of the Osher Center Leadership, Faculty and Fellows
2025
COSMOS Research Group. Long-Term Effect of Cocoa Extract Supplementation on Incident Hypertension. Hamaya R, Li S, Lau J, Allison M, Haring B, Shadyab AH, Matthew N, Martin LW, Rist PM, Manson JE, Sesso HD; Hypertension. 2025 Aug 20. doi: 10.1161/HYPERTENSIONAHA.125.25209.
Thank Efficacy of Non-Surgical Treatments for Acute Non-Specific Low Back Pain: Protocol for Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.Trager RJ, Baumann AN, Bejarano G, Burton W, Blackwood ER, Holmes BD, Goertz CM. BMJ Open. 2025 Jul 22;15(7):e100520. doi: 10.1136/bmjopen-2025-100520.
Patterns of Heart Rate Reduction During Sleep Onset in Participants With and Without Insomnia. Ma Y, Wayne PM, Mullington JM, Yeh GY. J Clin Sleep Med. 2025 Aug 1;21(8):1395-1405. doi: 10.5664/jcsm.11714.
Dignity-Based Care: Lessons for Today from Two Turning Points in the Histories of Acupuncture. Meng EX, Chao MT, Wayne P. J Integr Complement Med. 2025 Jul 14. doi: 10.1089/jicm.2025.0434.
Reimagining Integrative Medicine Fellowship Core Competencies with a Health Equity Lens. Minichiello V, Ring M, Adler SR, Bora S, Chiasson AM, Garber TS, Dhruva A, Hu K, Kogan M, Kohatsu W, Dog TL, Mehta DH, Rindfleisch A, Schneiderhan J, Soriano S. Am J Med. 2025 Jul 16:S0002-9343(25)00451-6.
Short- and Long-Term Natural History of Three Neurodegenerative Biomarkers Among Middle-Aged and Older Adults.Hamaya R, Rist PM, Kupelian V, Gotter AL, Sohn J, Rubel CE, Gaziano JM, Manson JE, Sesso HD. J Neuromuscul Dis. 2025 May 21:22143602241301636.
The Overlooked Impact of Background Diet and Adherence in Nutrition Trials. Ottaviani JI, Schroeter H, Bier DM, Erdman JW Jr, Sesso HD, Manson JE, Kuhnle GGC. Food Funct. 2025 Jul 14;16(14):5733-5743.
Resiliency Among Mass General Brigham Hospital Employees Post-COVID-19 Pandemic. Durieux N, Park ER, Hall D, Meek J, Fricchione G, Mehta DH, Luberto C Glob Adv Integr Med Health. 2025 Mar 4;14:27536130251325831.
Multidimensional Analysis of Twin Sets During an Intensive Week-Long Meditation Retreat: A Pilot Study. Zuniga-Hertz JP, Simpson S, Chitetti R, Hsu CF, Huang HP, Jinich-Diamant A, Chernov AV, Onton JA, Cuomo R, Dispenza J, Davis D, Christov-Moore L, Reggente N, Gu W, Kong M, Bonds JA, Maree J, Simonson TS, Ahn AC, Poirier MA, Moeller-Bertram T, Patel HH. Mindfulness (N Y). 2025;16(6):1634-1655.
Mindfulness and Tai Chi for Cancer Health (MATCH) Study: Primary Outcomes of a Preference-Based Multisite Randomized Comparative Effectiveness Trial. Carlson LE, Jones JM, Oberoi D, Piedalue KA, Wayne PM, Santa Mina D, Lawal OA, Speca M. J Clin Oncol. 2025 Jun 12:JCO2402540. doi: 10.1200/JCO-24-02540. Epub ahead of print. PMID: 40505072.
Combined Chiropractic Care and Tai Chi for Chronic Neck Pain: A Protocol for a Pilot Randomized Trial. Wayne PM, Vining R, Long CR, Burton WM, Litrownik D, Guzman J, Kilgore K, Hagan TJ, Rist PM, Kowalski MH. Contemp Clin Trials Commun. 2025 Apr 11;45:101482. doi: 10.1016/j.conctc.2025.101482.
Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 Years: A Randomized Clinical Trial. Rudman Spergel AK, Wu I, Deng W, Cardona J, Johnson K, Espinosa-Fernandez I, Sinkiewicz M, Urdaneta V, Carmona L, Schaefers K, Girard B, Paila YD, Mehta D, Callendret B, Kostanyan L, Ananworanich J, Miller J, Das R, Shaw CA. JAMA. 2025 Jun 10;333(22):1977-1987. doi: 10.1001/jama.2025.5646. PMID: 40332892; PMCID: PMC12060023.
Identification of Individuals who Benefit From Omega-3 fatty acid Supplementation to Prevent Coronary Heart Disease: A Machine-Learning Analysis of the VITAL.Hamaya R, Cook NR, Sesso HD, Mora S, Buring JE, Manson JE. Eur J Epidemiol. 2025 Jun 26. doi: 10.1007/s10654-025-01259-0. Epub ahead of print. PMID: 40569483.
The influence of sex: A Deep Dive into Reverse Total Shoulder Arthroplasty Outcomes.Lazaridou A, Rist PM, Brune D, Schneller T, Moroder P, Scheibel M.Semin Arthroplasty. 2025 Jun;35(2):263-269. doi: 10.1053/j.sart.2025.01.003. Epub 2025 Feb 19.PMID: 40519773
Use of the Brain Care Score to Estimate the Risk of Incident Cerebrovascular Events in Middle-Aged Women. Choksi D, Gutiérrez-Martínez L, Rist PM, Buring JE, Senff JR, Marini S, Kourkoulis C, Chemali Z, Newhouse A, Westover MB, Tanzi RE, Fricchione G, Singh S, Rosand J, Anderson CD, Yechoor N.Neurology. 2025 Jun 10;104(11):e213674. doi: 10.1212/WNL.0000000000213674. Epub 2025 May 16.
The Earthrise Community: Transforming Planetary Consciousness for a Flourishing Future. Prescott SL, Nusrat A, Scott R, Nelson D, Rogers HH, El-Sherbini MS, Bisram K, Vizina Y, Warber SL, Webb D.; 16(2):24.Challenges 2025. https://doi.org/10.3390/challe16020024
Pre-Pandemic Physical Activity and Early COVID-19 Pandemic Depressive Symptoms in Older Adults. Muñoz-Vergara D, Sesso HD, Kim E, Fava M, Lee IM, Buring JE, Manson JE, Wayne PM. J Integr Complement Med. 2025 Apr 16. doi: 10.1089/jicm.2024.0791.
Modulating mechanisms of adverse childhood experiences in a mindfulness-based intervention: preliminary insights from an opioid use disorder study. Joss D, Rosansky J, Gardiner P, Edwards RR, Weiss RD, Napadow V, Schuman-Olivier Z.Front Psychol. 2025 Apr 30;16:1529106. doi: 10.3389/fpsyg.2025.1529106.
Ten-Year Trends in Pharmacologic Management of Gastroesophageal Reflux Disease and Pediatric Feeding Disorders in Young Children. Hirsch S, Liu E, Nurko S, Rosen R. J Pediatr. 2025 Apr 27;283:114628. doi: 10.1016/j.jpeds.2025.114628. Epub ahead of print. PMID: 40300664.
Healing STEM: Harnessing Compassion, Mindfulness, and Emotional Regulation to Overcome Burnout. Yeh GY, Mehta DH, Wayne PM. J Integr Complement Med. 2025 Apr 16. doi: 10.1089/jicm.2025.0168. Epub ahead of print.
The Science of Tai Chi and Qigong and Whole Person Health – Part I: Rationale and State of the Science. Wayne PM, Ahn A, Clark J, Irwin MR, Kong J, Lavretsky H, Li F, Manor B, Mehling W, Oh B, Seitz D, Tawakol A, Tsang WWN, Wang C, Yeung A, Yeh GY. J Integr Complement Med. 2025 Mar 17. doi: 10.1089/jicm.2024.0957. Epub ahead of print.
The Science of Tai Chi and Qigong as Whole Person Health- Part II: Evidence Gaps and Opportunities for Future Research and Implementation. Yeh GY, Ahn A, Clark J, Irwin MR, Kong J, Lavretsky H, Li F, Manor B, Mehling W, Oh B, Seitz D, Tawakol A, Tsang WWN, Wang C, Yeung A, Wayne PM. J Integr Complement Med. 2025 Apr 14. doi: 10.1089/jicm.2024.0958. Epub ahead of print.
Remote monitoring of Tai Chi balance training interventions in older adults using wearable sensors and machine learning. Corniani G, Sapienza S, Vergara-Diaz G, Valerio A, Vaziri A, Bonato P, Wayne PM. Sci Rep. 2025 Mar
COSMOS Research Group. Cocoa flavanol supplementation and risk of age-related macular degeneration: An ancillary study of the COSMOS randomized clinical trial. Christen WG, Rist PM, Moorthy MV, Smith DC, Holman B, Clar A, Glynn RJ, Mares JA, Sobrin L, Shadyab AH, Allison MA, Millen AE, Manson JE, Sesso HD JAMA Ophthalmol. 2025 Mar 27.
US consumer and healthcare professional preferences for combination COVID-19 and influenza vaccines. Poulos C, Buck PO, Ghaswalla P, Rudin D, Kent C, Mehta D. J Med Econ.Epub 2025 Feb 20.
Advancing health equity in integrative health: the role of collaborative educational partnerships in addressing structural racism. Zhang X, Mullur RS, Riopelle C, Mehta DH, Vega N, Parker T, Soriano S, Price JR, Miller YM, Davis IJ, Chandran L. Glob Adv Integr Med Health. 2025 Jan 30
A meta-regression of psychosocial factors associated with sleep outcomes in mindfulness-based intervention trials. Choukas NR, Woodworth EC, Manglani HR, Greenberg J, Mace RABehav Sleep Med. 2025 Jan-Feb.
Patterns of Heart Rate Reduction During Sleep Onset in Participants With and Without Insomnia. Ma Y, Wayne PM, Mullington JM, Yeh GY. J Clin Sleep Med. 2025 Apr 15. doi: 10.5664/jcsm.11714. Epub ahead of print.
Pre-Pandemic Physical Activity and Early COVID-19 Pandemic Depressive Symptoms in Older Adults. Muñoz-Vergara D, Sesso HD, Kim E, Fava M, Lee IM, Buring JE, Manson JE, Wayne PM. J Integr Complement Med. 2025 Apr 16. doi: 10.1089/jicm.2024.0791. Epub ahead of print.
US consumer and healthcare professional preferences for combination COVID-19 and influenza vaccines. Poulos C, Buck PO, Ghaswalla P, Rudin D, Kent C, Mehta D. J Med Econ.Epub 2025 Feb 20.
Advancing health equity in integrative health: the role of collaborative educational partnerships in addressing structural racism. Zhang X, Mullur RS, Riopelle C, Mehta DH, Vega N, Parker T, Soriano S, Price JR, Miller YM, Davis IJ, Chandran L. Glob Adv Integr Med Health. 2025 Jan 30
Factors associated with longitudinal progression of the cumulative burden of morbidity and overall mortality after cisplatin-based chemotherapy for testicular cancer. JKerns SL, Dinh PC Jr, Monahan PO, Stump T, Fung C, Sesso HD, Feldman DR, Hamilton RJ, Vaughn DJ, Huddart R, Kollmannsberger C, Martin NE, Nevel K, Kincaid J, Einhorn LH, Travis LB. Natl Cancer Inst. 2025 Feb 3
Long-term follow up from the Harvard Alumni Health Study: collegiate sport participation in males is associated with higher physical activity throughout midlife. Wasfy MM, Siam UT, Gustus SK, Boyd KS, Tenforde AS, Sesso H, Lee IM. Br J Sports Med. 2025 Jan 29.
Age Self Care-Resilience, A Medical Group Visit Program Targeting Pre-frailty: A Mixed Methods Pilot Clinical Trial. J Frailty Aging. Epub 2025 Jan 1. Loewenthal JV, Burton W, Kamali S, Ramani S, Wayne PM, Orkaby AR, Aronson L.
Developing a Novel Integrative Health Equity and Anti-racism Tool (IHEART) for Pilot Application in a Multicenter Integrative Health Elective for Medical Students and Resident Physicians: A Study Protocol GAHM. 2025;14. Minichiello V, Ring M, Walsh EG, Mehta DH.
COSMOS Research Group. Long-Term Effect of Cocoa Extract Supplementation on Incident Hypertension. Hamaya R, Li S, Lau J, Allison M, Haring B, Shadyab AH, Matthew N, Martin LW, Rist PM, Manson JE, Sesso HD; Hypertension. 2025 Aug 20. doi: 10.1161/HYPERTENSIONAHA.125.25209.
Thank Efficacy of Non-Surgical Treatments for Acute Non-Specific Low Back Pain: Protocol for Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.Trager RJ, Baumann AN, Bejarano G, Burton W, Blackwood ER, Holmes BD, Goertz CM. BMJ Open. 2025 Jul 22;15(7):e100520. doi: 10.1136/bmjopen-2025-100520.
Patterns of Heart Rate Reduction During Sleep Onset in Participants With and Without Insomnia. Ma Y, Wayne PM, Mullington JM, Yeh GY. J Clin Sleep Med. 2025 Aug 1;21(8):1395-1405. doi: 10.5664/jcsm.11714.
A Pilot and Feasibility Analysis of Serum TMAO and Choline in a Randomized Sample from the COSMOS Trial. Gavilán IS, Li S, Sweet MG, Ratliff JG, Rist PM, Kim E, Manson JE, Sesso HD, Neilson AP. Food Funct. 2025 Oct 23.
Turning Down the Heat: Mind-Body Strategies Against Inflammaging. Mehta DH, Wayne PM, Yeh GY. J Integr Complement Med. 2025 Oct;31(10):852-856.
Relationships Between Trunk Endurance, Low Back Pain Severity and Functional Disability in a United States Veteran Population: A Cross-sectional Retrospective Study. Burton WM, Schielke AL, Butler RJ, Huberman DB, Kowalski MH,Wayne PM, Teraoka J, Vining R. J Manipulative Physiol Ther. 2025 Sep 27:S0161-4754(25)00005-3.
Promoting Walking in Cardiopulmonary Disease With Mindful Steps: Pilot Feasibility Randomized Controlled Trial of a Web-Based, Pedometer-Mediated Mind-Body Intervention. Kraemer KM, Litrownik D, Wayne PM, Richardson CR, Bhomia N, Kadri R, Rist PM, Ngo L, Moy ML, Yeh GY. JMIR Form Res. 2025 Oct 28;9:e74118.
Development of a Brief Mindfulness-Informed Cognitive-Behavioural Therapy Intervention to Pair With Pharmacist-Led Benzodiazepine Tapering for Older Adults: The CSTARS Intervention.Kraemer KM, Wang B, McCann M, Lindenberg J, Anderson TS, Yeh GY. Basic Clin Pharmacol Toxicol. 2025 Nov;137(5):e70128.
Longitudinal Changes in Epigenetic Measures Over 2 Years: Methodological Implications. Geroscience. Hamaya R, Li S, Chen BH, Pereira AC, Rigby N, Zhu H, Ivey KL, Rist PM, Manson JE, Dong Y, Sesso HD. 2025 Nov 11.
Non-acute Effects of Passive Heating Interventions on Cardiometabolic Risk and Vascular Health: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hamaya R, Joyama Y, Miyata T, Fuse SI, Yamane N, Maruyama N, Kanazawa H, Morishita K, Sesso HD. Am J Prev Cardiol. 2025 Aug 17;23:101082.
Artificial intelligence in Integrative Medicine: Transforming Education for a Digital Future. Mehta DH, Ring M. Integr Med Res. 2025 Dec;14(4):101259.
Bedtime App-Guided Mindfulness in Patients with Insomnia: Mixed Methods Feasibility and Acceptability Pilot Study Ma Y, Wayne PM, Mullington JM, Bertisch S, Yeh GY. JMIR Form Res. 2025 Sep.
Cannabis Education: A Professional and Moral Obligation for Physicians, Mehta DH. JAMA Netw Open. 2025 Oct.
Managing, Not Lessening, Uncertainty: A Novel Mind-Body Intervention for Fear of Cancer Recurrence. Christie AJ, Bolden C, Park ER, Yeh GY, O’Cleirigh C, Peppercorn J, Denninger JW, Hirschberg AM, Lee H, Markwart M, Siefring E, Mizrach HR, Bullock AJ, Hall DL. J Cancer Surviv. 2025 Sep 1. doi: 10.1007/s11764-025-01886-2.
Effects of 2-year Cocoa Extract Supplementation on Inflammaging Biomarkers in Older US Adults: Findings from the COcoa Supplement and Multivitamin Outcomes Study Randomised Clinical Trial. Li S, Hamaya R, Zhu H, Clar A, Rist PM, Huang Y, Manson JE, Sesso HD, Dong Y. Age Ageing. 2025 Aug 29;54(9):afaf269. doi: 10.1093/ageing/afaf269.
Assocation Between a Brain Care Score Derived from Participant Responses and Incident Stroke from the COSMOS Study. Senff JR, Tack RWP, Tan BYQ, Kimball TN, Prapiadou S, Choksi D, Ranman TH, McVeigh TM, Shadyab AH, Brouwers HB, Manson JE, Sesso HD, Anderson CD, Rosand J, Singh SD, Rist PM, Yechoor N.Am J Lifestyle Med. 2025 Aug 22:15598276251368345. doi: 10.1177/15598276251368345.